- 作者: Ru Ping Lee a,b, David Wang c, Nien Tsung Lin d, Hsing I. Chen a,e
- 作者服務機構: a Institute of Medical Sciences, b Department of Nursing, c Department of Nursing, Tzu Chi College of Technology, Cheng Hsin General Hospital, d Department of Microbiology ,and e Department of Physiology, Tzu Chi University, Hualien, Taiwan
- 中文摘要: --
- 英文摘要: AP, HR, WBC, free radicals, and chemical substances(BUN, Cr) can possibly serve as approximate indicatorsfor the early stage of endotoxin shock. Severe multipleorgan damage may be caused by amylase release in thelate stage of endotoxin shock.Endotoxin shock is a major cause of death in patientswith septicemia. Endotoxin induces nitric oxide (NO)production and causes tissue damage. In addition, therelease of oxygen free radicals has also been observed inendotoxin shock and was found to be responsible for theoccurrence of multiple organ failure. The purpose of thepresent study was to evaluate suitable indicators for ear-1y and late stages of endotoxin shock. The experimentswere designed to induce endotoxin shock in consciousrats by means of an Escherichia coli lipopolysaccharide(LPS) injection. Arterial pressure (AP) and heart rate (HR)were continuously monitored for 72 h after LPS adminis-tration. The maximal decrease in AP and increase in HRand nitrate/nitrite level occurred at 9-12 h following LPSadministration. The white blood cell (WBC) count haddecreased at 3 h. Hydroxyl radical (methyl guanidine,MG) decreased rapidly after LPS administration. Plasmalevels of blood urea nitrogen (BUN), creatinine (Cr), lacticdehydrogenase (LDH), creatine phosphokinase (CPK),and glutamic oxaloacetic transaminase increased beforethe rise of amylase. Our results suggest that changes in
- 中文關鍵字: --
- 英文關鍵字: Conscious rat, Physiological parameters, Endotoxin shock, Multiple organ failure, Chemical factors