• 作者： Wang, Da-Ming; Yeh, Hsiu-Min; Lai, Juin-Yih
• 中文摘要： 本研究係探討溶媒對藥物透過高分子膜速率之影響，所使用的溶媒為乙醇-水溶液，可藉由調整乙醇濃度來變化溶媒之性質，所選用的膜材為聚胺甲酸酯，而使用的藥物是硝化甘油。實驗結果顯示，溶媒中乙醇濃度增加會有兩種效應：一是增加硝化甘油在溶媒中之溶解度，而降低其在膜中之分配係數；另一則是提高溶媒對膜之膨潤度而提高硝化甘油在膜中之擴散係數。當乙醇濃度低於65 wt%時，分配之效應較明顯，故硝化甘油之透過性隨乙醇濃度昇高而變小; 而當乙醇濃度大於65wt%時，膨潤之效應較明顯，故硝化甘油之透過性隨乙醇濃度昇高而變大。由於此兩效應間相互競爭，在溶媒中之乙醇濃度約為65wt%時，硝化甘油有最低之透過性。
• 英文摘要： In the present work, the effect of medium on the drug permeation rate through polymeric membranes was investigated. The medium used in this work was ethanol-water solution of which the property can be adjusted by varying the ethanol composition. The membrane used was the polyurethane membrane and the model drug was nitroglycerin. The results indicate that an increase in the ethanol concentration in medium can have two effects: it can increase the nitroglycerin solubility in the donor and thus decrease the partition coefficient, and it can increase the degree of swelling of the polyurethane membrane and thus result in higher nitroglycerin diffusivity. When the ethanol concentration is lower than 65wt%, the effect of partition dominates and increasing ethanol concentration results in decreasing nitroglycerin permeability. On the other hand, when the ethanol concentration is higher than 65wt%, the effect of swelling on diffusivity dominates and increasing ethanol concentration results in increasing nitroglycerin permeability. Due to the competition between these two effects, a minimum nitroglycerin permeability occurs when the ethanol concentration is around 65wt%.
• 中文關鍵字： 藥物輸送; 溶媒體; 聚胺酯; 膨潤; 分配
• 英文關鍵字： Drug Transport; Lysosome; Polyurethane (Pu); Swelling; Partition