- 作者: Marcia Alves Marques Capella Luiz Sabbatini Capella
- 作者服務機構: Instituto de Biofisica Carlos Chagas Filho, Departamento de Bioquimica Medica, Universidade Federal do Rio de Janeiro, Departmento de Clinica Medica, Universidade do Rio de Janeiro, Rio de Janeiro, Brasil
- 中文摘要: --
- 英文摘要: The major drawback of cancer chemotherapy is thedevelopment of multidrug-resistant (MDR) tumor cells,which are cross-resistant to a broad range of structurallyand functionally unrelated agents, making it difficult totreat these tumors. In the last decade, a number ofauthors have studied the effects of photodynamic thera-py (PDT), a combination of visible light with photosensi-tizing agents, on MDR cells. The results, although stillinconclusive, have raised the possibility of treating MDRtumors by PDT. This review examines the growing litera-ture concerning the responses of MDR cells to PDT, whilestressing the need for the development of new photo-sensitizers that possess the necessary characteristics forthe photodynamic treatment of this class of tumor.
- 中文關鍵字: --
- 英文關鍵字: Mulitidrug resistance. Visible light. Phototherapy. Photosensitizer. Review