- 作者: Leena Kuruvilla; Chandrasekharan Cheranellore Kartha; C.C.Kartha
- 作者服務機構: Division of Cellular & Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, India
- 中文摘要: --
- 英文摘要:
Background:
The endocardial endothelium that lines the inner cavity of the heart is distinct from the
microvascular endothelial cells and modulates cardiac muscle performance in a manner
similar to the vascular endothelial modulation of vascular structure and vasomotor tone.
Although the modulatory effects of endocardial endothelium (EE) on cardiomyocytes are
firmly established, the regulatory effects of endocardial endothelium on the cardiac
interstitium and its cellular components remain ill defined.
Methods and Results:
We investigated whether the stimulatory effect of EE on cardiac fibroblasts would be
altered when EECs are activated by the cytokine tumor necrosis factor-α (TNF-α) or the
endotoxin bacterial lipopolysaccharide (LPS). Both TNF-α and LPS were found to
independently attenuate the stimulatory effect of EE on cardiac fibroblasts. These agents
lowered the synthesis or release of ET-1 and increased the secretion of TGF-β and NO.
Conclusion:
The findings of this study using endocardial endothelial cells (EECs) and neonatal
cardiac fibroblasts demonstrate that pro-inflammatory cytokines cause altered secretion
of paracrine factors by EECs and inhibit proliferation and lower collagen synthesis in
fibroblasts. These changes may influence fibroblast response and extra cellular matrix
remodeling in pathological conditions of the heart. - 中文關鍵字: --
- 英文關鍵字: --