- 作者: Geng-Chang Yeh Pao-Luh Tao Hsiu-O Ho Yung-Jin Lee Julia Yi-Ru Chen Ming-Thau Sheu
- 作者服務機構: Department of Pediatrice, Taipei Medical University Hospital, Graduate Institute of Medical Science, College of Medicine, Department of Pharmacology, National Defense Medical Center, School of Pharmacy, Graduate Institute of Pharmaceutical Ssiences, College of Pharmacy, Taipei Medical University, Taipei, and College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
- 中文摘要: --
- 英文摘要: In this study, the metabolic ratios of dextromethorphanto dextrorphan(DM/DX) in plasma were calculated atsteady state after administering 2 dosage forms(Medi-con and Detusiv.) of DM with different release rates.The urinary metabolic ratio for each subject was alsodetermined based on the total drug concentration in theurine. An analysis of pharmacokinetic parameters fordetermining the DM metabolic phenotype was con-ducted.Results demonstrate that double logarithmic cor-relations between the metabolic ratios based on phar-macokinetic parameters of either AUCo_T,SS, Cmax,ss,Cmin,ss, or Cave,ss for Medicon and Detusiv and the urinarymetabolic ratios were all significant. Probit plots of themetabolic ratios based on these pharmacokinetic param-eters revealed 2 clusters of distribution,representingextensive and intermediate metabolizers. An antimodeof 2.0 for total drug based on these pharmacokineticparameters was determined and correspondingly re-ferred to an antimode of 0.02 for the urinary metabolicratio to delineate extensive and intermediate metabo-lizers.This model was also verified to be appropriatewhen using total plasma concentrations of DM and DX atany time during the period of the dosing interval atsteady state to calculate the metabolic ratio for identi-fying extensive and intermediate metabolizers.There-fore, the metabolic ratio based on the pharmacokineticparameters of either AUCo_T,SS, Cmax,ss, Cmin,ss, Or Cave,ssand plasma concentrations of DM and DX in a singleblood sample at steady state are proposed as an alterna-tive way to identify phenotypes of CYP2D6.
- 中文關鍵字: --
- 英文關鍵字: Dextromethorphan. Dextrorphen. Metabolic ratio. Pharmacokinetic parameters. Steady state