- 作者: 張祖辛 ; 王志偉 ; 周義敏 等
- 作者服務機構: 中山大學化學系
- 中文摘要: The HAPP-Fe complex was more active than HAPP-Cu complex in cleavage of DNA in the presence of dithiothreitol and hydrogen peroxide. In contrast, the HAPP-Cu complex was found to bind more strongly with .lambda.-DNA, whereas the HAPP-Fe binds weakly. It was shown that the metal ion complexed with HAPP ligand can influence the binding and cleaving activity due to the ability of the ligand to undergo geometrical tautomerization.
- 英文摘要: --
- 中文關鍵字: Dna Binding Affinity; Dna Cleavage; Metal Ion; Nuclease; Hexaazacyclophane
- 英文關鍵字: 去氧核糖核酸結合親和性;去氧核糖核酸斷裂;金屬離子;核酸