- 作者: Synthesis of Thymidine Dimer Containing Novel (N-Acetyl)imino Linkage
- 中文摘要:
Department of Applied Chemistry, Chaoyang University of Technology, Wufeng 413, Taichung, Taiwan, R.O.C.
By starting with 3¢-keto-5¢-O-protected thymidine, 3¢-O-amino-5¢-t-butyl-diphenylsilyl thymidine (9) was prepared and coupled with 3¢-O-t-butyl-diphenylsilyl-5¢-formyl thymidine to form a nucleoside dimer (11) containing oxime linkage. The backbone of this dimer, then, underwent reduction followed by acetylation to give an (N-acetyl)imino linkage, and a novel dinucleotide (13) was obtained. - 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --