- 作者: 王有智;郭重雄;林欣榮
- 中文摘要: The cold season of a year has been reported to have the highest incidence of strokes. Present studies were designed to test whether the parasympathetic denervation plays any role in the regulation of local cerebral blood flow (LCBF) in anesthetized animals exposed to a cold environment. Each species of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was divided into four groups: sphenopalatine postganglionic neurotomy (SPNx) or a control group at room temperature (20.degree.C) or in a cold environment (5.degree.C), respectively. LCBF in 14 brain structures was measured using the [/sup 14/C] iodoantipyrine technique and tissue dissecting methods. Our results show that SPNx did not significantly alterphysi- ological parameters and LCBF in WKY and SHR kept at either 20.degree.C or 5.degree.C. However, 30 minutes of cold exposure caused a significant decrease in the core body temperature of both the WKY and SHR groups (P < 0.05, Student's paired t-test) and a significant decrease in LCBF in 3 of 14 brain areas: the temporal cortex (TC), inferior colliculus (IC) and vermis (VER) of both WKY and SHR (P <0.05, MANOVA). The percentages of decrease were 24% (TC), 12% (IC), 12% (VER) and 19% (TC), 16% (IC), 15% (VER), respectively. Our findings indicate that in a cold environment, the lower LCBFs in some areas of the brain may be related to decreased body temperature. Whether they are related to the higher prevalence of stroke in winter needs further investigation.
- 英文摘要: --
- 中文關鍵字: sphenopalatine postganglionic neurotomy; local cerebral blood flow; cold stress; normotensive rat; spontaneous hypertensive rat
- 英文關鍵字: --