• 作者： 畢萬邦; 彭明聰; 潘麗玲; 賴連春
• 作者服務機構： 國立臺灣大學醫學院生理學科
• 中文摘要： 利用「卵巢激素有促進黃體生成激素潮放（surge）的效應」，來觀察此種效應在生存期已二年以上的年老雌鼠是否仍然存在。年老雌鼠包括持久乏情者（anestrus）和持久動情者（persistentestrus）兩種。在卵巢切除之後不同時期處理二氫氧女性素及助孕素或安息香酸二氫氧女性素及助孕素。但是用這些卵巢激素並不能使年老持久乏情鼠和多數的年老持久動情鼠血液中黃體生成激素的濃度升高，另外少數的年老持久動情鼠，血液中黃體生成激素濃度有升高的反應。結果說明在老化過程中，下視丘－－－腦下腺系對卵巢激素引發分秘黃體生成激素的反應已減低或已喪失。
• 英文摘要： The effect of ovarian steroid hormones infacilitating the surge of the luteinizing hormone(LH) has been examined in the 2-year-old,anestrus (AE) and persistent estrus (PE), femalerats. These rats were ovariectomized and treatedwith either estradiol and progesterone orestradiol benzoate and preogesterone at differenttime after ovariectomy. Ovarian steroid hor-mones failed to produced a rise in plasma LH inold AE rats and most of old PE rats, but elevatedplasma LH levels in a few of old PE rats. Theseresults suggest that the responsiveness of thehypothalamic-hypophyseal system to ovariansteroid hormones in initiating LH secretion wasdecreased and/or lost in the development ofageing.
• 中文關鍵字： --
• 英文關鍵字： --