- 作者: J. Pandya A. Chakraborti Y. Chawla
- 作者服務機構: Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Tex., USA, and Departments of Experimental Medicine and Biotechnology, and Hepatology, Post Graduate Institute of Medical Education and Reserch, Chandigarh, India
- 中文摘要: --
- 英文摘要:
Glycoproteins on the surface of viral particles present the
main target of neutralizing antibodies. The structural
proteins of most Flaviviruses are known to elicit neutral-
izing antibodies and, thus, to help in both the natural
resolution of the infection and the protection from chal-
lenge with homologous hepatitis C virus (HCV). Because
such antigens are associated with the viral clearance in
both humans and chimpanzees, we aimed to express the
E2/NS1 protein of HCV and to study the role of anti-E2/
NS1 antibodies in the natural resolution of HCV infection.
The prevalence of anti-E2/NS1 antibodies to recombi-
nant E2/NS1 protein was seen by Western blot in chronic
liver disease patients (15 chronic hepatitis and 12 cirrhot-
ic patients) ,who were positive for anti-HCV and negative
for HBV infection. The study also included 2 negative
controls (positive for HBV infection and negative for anti-
HCV antibodies) and 2 healthy controls (negative for
both HBV and HCV infection) . Anti-E2/NS1 was present in
20% of the chronic hepatitis and 16% of the cirrhosis
patients. None of the controls were positive for anti-E2/
NS1 antibodies. Serum samples positive for anti-E2/NS1
antibodies were also positive for HCV RNA by RT/PCR.
Accordingly, the presence of anti-E2/NS1 may have very
little or no role in the natural resolution of HCV infec-
tion. - 中文關鍵字: --
- 英文關鍵字: Anti-E2/NS1 prevalence. Chronic Hepatitis. E2/NS1. Hepatitis C virus. Infection. Neutralizing Antibodies