• 作者： 陳瑩霖; 顏全敏
• 作者服務機構： 高雄醫學院寄生蟲學科
• 中文摘要： 民國六十九年七月至七十年六月一年間在臺東縣延平鄉對村民及學童做中華肝吸蟲的皮內反應及糞便檢查外，對流行地區的感染者也做肝功能檢查，血清免疫診斷之嘗試、免疫球蛋白之測定及藥物治療效果之評估等。 皮內反應檢查結果，286 名受檢學童呈現陽性及疑陽性反應者同為 1.8%，而394 名受檢村民則分別為3.6%及1.8%，唯糞便檢查均未發現肝吸蟲卵。 24名感染者接受四項肝功能檢查（Total bilirubin, SGPT.SGOT和Alkalinephosphatase），其中16名（66.7%）有一項或以上高於正常值。感染者之免疫診斷則顯示 enzyme-linked immunosorbent assay (ELISA) 可檢抗體效價介於1,600倍與25,600倍之間，Complement fixation test (CFT)可檢抗體效價則介於16倍與128倍之間。免疫球蛋白之測定則顯示感染者血清中 IgG 及IgE 有意義的高於未感染者。 以 Praziquantel 治療74名感染者（每公斤體重 25mg，每天服藥三次），其中38名服藥一天，另36名服藥兩天，前者治癒率為100% (35/35)，後者為97.1%(33/34)，服藥後之副作用，以頭暈最常見，前者為68.4%，後者為62.9%，副作用均屬一過性。
• 英文摘要： From July 1980 to June 1981, ahuman survey for clonorchiasis wasperformed by skin testing and stoolexamination among school children andvillagers in Yen-Ping Hsiang, TaitungCounty, east Taiwan. In addition,during this same study year, activelyinfected patients were evaluated byliver function tests, immunodiagnostictechniques, serum immunoglobulins,and trial treatment with a new antihel-minthic drug. The results were asfollows: 1. Skin tests performed in 286school children and 394 villagers reve-aled 1.8% and 3.6% positive reactionrates, respectively, although stool ex-aminations in these individuals wereall negative for Clonorchis eggs. 2. Liver function tests includingfour items, i.e. total bilirubin, SGPT,SGOT and alkaline phosphatase wereperformed on 24 infected patients; 16patients or 66.7% showed one or moreitems with a test value higher thanthat of control group. 3. For immunodiagnosis, the enzy-me-linked immunosorbent assay andcomplement-fixation techniques wereutilized. Antibody dilution titers of 22clonorchiasis patients were between1,600 and 25,600 by ELISA; titersobtained by complement fixation werebetween 16 and 128. Both sets ofresults were higher than those of con-trols. 4. The values of IgG and IgE ofinfected patients were significantlyhigher than those of non-infectedcontrols. 5. Praziquantel, a new antihelmin-thic was given, to 74 patients in adosage of 25 mg/kg tid. The cure ratesafter one and two days of treatmentwere 100% and 97.1% respectively.Dizziness was the most common side-effect; however it was mild and tran-sient, it occurred in two-thirds ofpatients treated.
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