- 作者: Martina Werle; Lothar Jahn ; Jorg Kreuzer; Julia Hofele; Albrecht Elsasser; Cordula Ackermann; Hugo A. Katus; Achim M. Vogt
- 作者服務機構: 1 Innere Medizin III, Universitat Heidelberg, Heidelberg, Germany; ; 2 Praxis fur Kardiologie/Pneumologie, Aachener Str. 327, D-50931, Koln, Germany
- 中文摘要: --
- 英文摘要: The accumulation and proliferation of vascular smooth muscle cells (VSMC) within the vessel wall is an important pathogenic feature in the development of atherosclerosis. Glucose metabolism has been implicated to play an important role in this cellular mechanism. To further elucidate the role of glucose metabolism in atherogenesis, glycolysis and its regulation have been investigated in proliferating VSMC. Platelet derived growth factor (PDGF BB)-induced proliferation of VSMCs significantly stimulated glucose flux through glycolysis. Further evaluating the enzymatic regulation of this pathway, the analysis of flux:metabolite co-responses revealed that anaerobic glycolytic flux is controlled at different sites of gyc-olysis in proliferating VSMCs, being consistent with the concept of multisite modulation. These findings indicate that regulation of glycolytic flux in proliferating VSMCs differs from traditional concepts of metabolic control of the Embden-Meyerhof pathway.
- 中文關鍵字: --
- 英文關鍵字: atherosclerosis, metabolic control analysis, proliferation, vascular smooth muscle cells, Warburg effect