- 作者: 翁啟惠;陳順文;何純郎;王光燦
- 作者服務機構: 中央研究院生物化學研究所
- 中文摘要: 臺灣飯匙倩蛇神經毒蛋白已利用固相法完全合成,所得產物經純化後具頸肌神經—肌間傳導抑制作用活性與天然神經毒約相同,對小白鼠內腹膜注射的致死半量約0.2 μg/g
- 英文摘要: Taiwan Cobra (Naja naja atra) neurotoxin has been synthesized by Merrified's solid-phase method. The peptide obtained after purification was found nearly as potent as the neurotoxin in causing neuromuscular blockade in the chick biventer cervicis nerve-muscle prepartion. The LD50 in mice was found about 0.2 μg per gram of body weight.
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