- 作者: Fusheng Zhang, Jinshuai Guo, Zhenghou Zhang, Meiqi Duan, Guang Wang, Yiping Qian, Haiying Zhao, Zhi Yang & Xiaofeng Jiang
- 作者服務機構: 1.Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shenyang, China 2.Fusheng Zhang and Jinshuai Guo contributed equally to this work
- 中文摘要:
- 英文摘要:
Abstract
All cells, including prokaryotes and eukaryotes, could release extracellular vesicles (EVs). EVs contain many cellular
components, including RNA, and surface proteins, and are essential for maintaining normal intercellular communication and homeostasis of the internal environment. EVs released from diferent tissues and cells exhibit excellent
properties and functions (e.g., targeting specifcity, regulatory ability, physical durability, and immunogenicity), rendering them a potential new option for drug delivery and precision therapy. EVs have been demonstrated to transport
antitumor drugs for tumor therapy; additionally, EVs’ contents and surface substance can be altered to improve their
therapeutic efcacy in the clinic by boosting targeting potential and drug delivery efectiveness. EVs can regulate
immune system function by afecting the tumor microenvironment, thereby inhibiting tumor progression. Codelivery systems for EVs can be utilized to further improve the drug delivery efciency of EVs, including hydrogels
and liposomes. In this review, we discuss the isolation technologies of EVs, as well as engineering approaches to their
modifcation. Moreover, we evaluate the therapeutic potential of EVs in tumors, including engineered extracellular
vesicles and EVs’ co-delivery systems.
Highlights
1. Technologies such as microfuidics can improve EVs isolation efciency.
2. Engineering technologies can improve EVs drug loading efciency and tumor targeting.
3. EVs-based drug co-delivery systems are being developed, such as those with liposomes and hydrogels - 中文關鍵字:
- 英文關鍵字: Extracellular vesicles, Drug delivery system, Targeted tumor therapy, Mesenchymal stem cells