- 作者: Rasmus O Bak; Jacob G Mikkelsen
- 作者服務機構: Department of Human Genetics, University of Aarhus, DK-8000 Aarhus C, Denmark
- 中文摘要: --
- 英文摘要:
Intercellular signaling by cytokines is a vital feature of the innate immune system. In skin, an inflammatory
response is mediated by cytokines and an entwined network of cellular communication between T-cells and
epidermal keratinocytes. Dysregulated cytokine production, orchestrated by activated T-cells homing to the
skin, is believed to be the main cause of psoriasis, a common inflammatory skin disorder. Cytokines are
heavily regulated at the transcriptional level, but emerging evidence suggests that regulatory mechanisms
that operate after transcription play a key role in balancing the production of cytokines. Herein, we review
the nature of cytokine signaling in psoriasis with particular emphasis on regulation by mRNA destabilizing
elements and the potential targeting of cytokine-encoding mRNAs by miRNAs. The proposed linkage
between mRNA decay mediated by AU-rich elements and miRNA association is described and discussed as
a possible general feature of cytokine regulation in skin. Moreover, we describe the latest attempts to
therapeutically target cytokines at the RNA level in psoriasis by exploiting the cellular RNA interference
machinery. The applicability of cytokine-encoding mRNAs as future clinical drug targets is evaluated, and
advances and obstacles related to topical administration of RNA-based drugs targeting the cytokine circuit
in psoriasis are described. - 中文關鍵字: --
- 英文關鍵字: --