- 作者: M.R. Batista R. Curi F.B. Lima G. Lopes R.B. Bazotte
- 作者服務機構: Department of Pharmacy and pharmacology, State University of Maringa, Maringa, Parana, Department of Physiology and Biophysics, State University of Sao Paulo, Sao Paulo, Sao Paulo, Brazil
- 中文摘要: --
- 英文摘要: We investigated the effect of a meal feeding schedule(MFS) on food intake, hepatic glycogen synthesis, hepat-ic capacity to produce glucose and glycemia in rats. TheMFS comprised free access to food for a 2-hour perioddaily at a fixed mealtime (8.00-10.00 a.m.) for 13 days.The control group was composed of rats with free accessto food from day 1 to 12, which were then starved for22 h, refed with a single meal at 8.00-10.00 a.m. andstarved again for another 22 h. All experiments were per-formed at the meal time (i.e.8.00 a.m.). The MFS groupexhibited increased food intake and higher glycogensynthase activity. Since gluconeogenesis from L-gluta-mine or L-alanine was not affected by MFS, we concludethat the increased food intake and higher glycogen syn-thase activity contributed to the better glucose mainte-nance showed by MFS rats at the fixed meal time.
- 中文關鍵字: --
- 英文關鍵字: Meal feening. Feeding behavior. Liver metabolism. Metabolic adaptations. Hepatic gluconeogenesis. Glycemia. Ureagenesis. Glycogen synthase