- 作者: Junhua Xiaoa, Gu Yuana, Weiqiang Huanga, John H. K. Lumb, K-L Daniel Leeb and Albert S. C. Chanb
- 作者服務機構: Department of Chemical Biology, The Key Laboratory of Bioorganic Chemistry and Molecular Engineering , (Ministry of Education, China), Peking University, Beijing 100871, China
- 中文摘要: Two nitrated analogs of distamycin were synthesized by a novel haloform reaction and the DCC/HOBT coupling reaction in a convenient and effective way without amino group protection. Our results have demonstrated that these polyamides show DNA cleaving activity under long UV (LUV 365 nm) irradiation. Furthermore, it is an unexpected discovery that these analogs can prevent DNA damage under short UV (SUV 302 nm).
- 英文摘要: --
- 中文關鍵字: --
- 英文關鍵字: --