- 作者: Jianxin Ye, Ling Li, Yuanting Zhang, Xueguang Zhang, Daming Ren and Weichang Chen
- 作者服務機構: Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China
- 中文摘要: --
- 英文摘要:
Background: Immunotherapy with vaccines is attractive for the treatment of cancer. This study is aimed at determining the effect of recombinant Salmonella (SL3261)-based 4-1BB ligand (4-1BBL) vaccine on the development of colorectal cancers and the potential immune mechanisms in rats.
Results: In comparison with that in the PBS group, similar levels of 4-1BBL expression, the frequency of T cells, IFN-gamma responses, and comparable numbers of tumors were detected in the SL3261 and SL3261C groups of rats. In contrast, significantly fewer numbers of tumors, increased levels of 4-1BBL expression in the spleens and colorectal tissues, higher frequency of peripheral blood and splenic CD3+CD25+ T cells, and stronger splenic T cell IFN-gamma responses were detected in the SL3261R group of rats.
Conclusion: Our results indicated that vaccination with recombinant attenuated Salmonella harboring the 4-1BBL gene efficiently enhanced T cell immunity and inhibited the development of carcinogen-induced colorectal cancers in rats. - 中文關鍵字: --
- 英文關鍵字: Recombinant attenuated Salmonella, Colorectal cancer, 4-1BBL, T cell-based cellular immunity