- 作者: 劉雨田; 何東英; 李安榮; 陳家福; 陳豪勇; 陳聰仁
- 作者服務機構: 國防醫學院微生物學研究所; 國立臺灣大學化學系; 國防醫學院藥學系; 三軍總醫院醫學研究院; 科技中心
- 中文摘要: 中華黴素A係由本省分離之鏈絲菌株No. PL-D-5所產生之新抗癌抗生素。依其物化特性的研究結果顯示中華徽黴A屬於actinomycin類之抗生素,其化學分子式為(方程式無法摘錄)。此抗生素可以有機溶劑自醱酵液中抽取出,經純化後為一紅色結晶。中華黴素A除了有抗血癌細胞(P388 mouse leukemia)活性外,亦具有很強的抗革蘭氏陽性細菌活性,但對革蘭氏陰性細菌和黴菌則無抗菌活性。
- 英文摘要: Chounghwamycin A, a new antitumor antibiotic produced by a strain of Streptomyces sp. No.PL-D-5, was isolated and characterized. It appeared to belong to the actinomycin group of antibiotics fromphysico-chemical studies and has an empirical formula of (方程式無法摘錄). The antibiotic is extractable intoan organic solvent from the fermentation broth, possessing potent antileukemic activity against P388 mouseleukemia in mice and antimicrobial activity against Gram-positive bacteria with MIC values about 0.1-0.4μg/ml, but showed no activity on Gram-negative bacteria, yeast and fungi tested.
- 中文關鍵字: choungh wamycin A; chounghwamycin B; antitumor antibiotic; actinomycin group
- 英文關鍵字: --