- 作者: Yi-Heng Li, Cheng-Hsiang Kuo, Guey-Yueh Shi and Hua-Lin Wu
- 作者服務機構: Department of Internal Medicine, National Cheng Kung University, Tainan, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety
of cell types. It is a cofactor for thrombin binding that mediates protein C activation and
inhibits thrombin activity. In addition to its anticoagulant activity, recent evidence has
revealed that TM, especially its lectin-like domain, has potent anti-inflammatory function
through a variety of molecular mechanisms. The lectin-like domain of TM plays an important
role in suppressing inflammation independent of the TM anticoagulant activity. This article
makes an extensive review of the role of TM in inflammation. The molecular targets of TM
lectin-like domain have also been elucidated. Recombinant TM protein, especially the TM
lectin-like domain may play a promising role in the management of sepsis,
glomerulonephritis and arthritis. These data demonstrated the potential therapeutic role of
TM in the treatment of inflammatory diseases. - 中文關鍵字: --
- 英文關鍵字: Thrombomodulin, Lectin, Inflammation