- 作者: Richard J. Bodnar
- 作者服務機構: Department of Psychology and Neuropsychology Doctoral Subprogram, Queens College, City University of New York, Flushing, N.Y,. USA
- 中文摘要: --
- 英文摘要: Supraspinal opioid antinociception is mediated by sensi-tive brain sites capable of supporting this response fol-lowing microinjection of opioid agonists. These sitesinclude the ventrolateral periaqueductal gray (vIPAG),the rostral ventromedial medulla (RVM), the locus coeru-leus and the amygdala. Each of these sites comprise aninterconnected anatomical and physiologically relevantsystem mediating antinociceptive responses through re-gional interactions. Such interactions have been identi-fied using two pharmacological approaches:(1) the abili-ty of selective antagonists delivered to one site to blockantinociception elicited by opioid agonists in a secondsite, and (2) the presence of synergistic antinociceptiveinteractions following simultaneous administration ofsubthreshold doses of opioid agonists into pairs of sites.Thus, the RVM has essential serotonergic, opioid, cholin-ergic and NMDA synapses that are necessary for the fullexpression of morphine antinociception elicited from thevIPAG, and the vIPAG has essential opioid synapses thatare necessary for the full expression of opioid antinoci-ception elicited from the amygdala. Further, the vIPAG;RVM, locus coeruleus and amygdala interact with eachother in synergistically supporting opioid antinocicep-tion.
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- 英文關鍵字: --