• 作者： Tzu-Ting Lai, Chia-Wei Liou, Yu-Hsuan Tsai, Yuan-Yuan Lin & Wei-Li Wu
• 作者服務機構： 1.Department of Physiology, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan, 70101, Taiwan 2.Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan, 70101, Taiwan
• 中文摘要：
• 英文摘要：
  Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk of numerous psychiatric disorders. Accumulating evidence suggests that the gut and its inhabiting microbes may regulate stress and stress-associated behavioral abnormalities. Hence, the objective of this review is to explore the causal relationships between the gut microbiota, stress, and behavior. Dysbiosis of the microbiome after stress exposure indicated microbial adaption to stressors. Strikingly, the hyperactivated stress signaling found in microbiota-deficient rodents can be normalized by microbiota-based treatments, suggesting that gut microbiota can actively modify the stress response. Microbiota can regulate stress response via intestinal glucocorticoids or autonomic nervous system. Several studies suggest that gut bacteria are involved in the direct modulation of steroid synthesis and metabolism. This review provides recent discoveries on the pathways by which gut microbes affect stress signaling and brain circuits and ultimately impact the host’s complex behavior.
• 中文關鍵字：
• 英文關鍵字： Gut-brain axis, Microbiota, Microbiome, Stress, Corticosterone, Intestinal steroidogenesis, Neural circuits, Autonomic nervous system, Probiotic, Prebiotic