- 作者: Osama S. Moustafa
- 作者服務機構: Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
- 中文摘要: 3-(p-Acetyl-anilinomethyl)quinoxalin-2(1H)-one (3) was prepared by the reaction of 3-bromomethylquinoxalin-2(1H)-one (1) with p-aminoacetophenone (2) in pyridine. Reaction of p-acetylcompound (3) with aromatic aldehydes yield the corresponding chalcones (4a-c). Condensation of latter chalcones with malononitrile afforded cyanopyridines (5a-c). Also, the reaction of chalcones (4a-c) with hydroxylamine hydrochloride furnished isoxazoles (6a-c). The reaction of bromo compound (1) with p-aminobenzophenone yield (8) which was condenced with hydrazine hydrate to get the corresponding hydrazone derivatives (9). Some of the synthesized compounds have been screened for their antimicrobial activity against various strains of bacteria and fungi .
- 英文摘要: --
- 中文關鍵字: Quinoxaline; Isoxazoles; Antimicrobial activity.
- 英文關鍵字: --