- 作者: Andrew D. Farmer; Charles E. Calef; Kim Millman; Gerald L. Myers
- 作者服務機構: Theoretical Biology and Biophysics (T-10), Theory Division, Los Alamos National; Laboratory, Los Alamos, N.M., USA
- 中文摘要: --
- 英文摘要: Papillomaviruses are responsible for a variety of diseases in humans and ani- mals, ranging from harmless skin warts to lethal cancers. They also make up one of the most genetically diversified families of viruses known, and could represent a model system of DNA-virus evolution. A specialized genetic sequences database, The Human Papillomavirus Database and Analysis Pro- ject, was recently established in an effort to provide database services that are specific to papillomaviruses to the research community and to perform a vari- ety of sequence-based analyses. This review is intended to present the scope of the information currently contained in the database and to outline some of the analyses that have been performed on the genetic sequences. These analyses will address issues including phylogenetic relationships, recombination events, selective pressures on different genes and the possibility of cross-spe- cies transmission in the case of the papillomaviruses.
- 中文關鍵字: --
- 英文關鍵字: Papillomaviruses; Genetic sequence database; Sequence analysis; Phylogenetic trees