- 作者: Christine Neuveut Robert M. Scoggins David Camerini Richard B. Markham Kuan-Teh Jeang
- 作者服務機構: Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Md.; Myles H. Thaler Center for AIDS and Human Retrovirus Research, University of Virginia Health Science Center, Charlottesville, Va.; Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Md., USA
- 中文摘要: --
- 英文摘要: HIV-1 Tat is essential for virus replication and is a potenttransactivator of viral gene expression.Evidence sug-gests that Tat also influences virus infectivity and cytopa-thicity. Here, we find that the second coding exon of Tatcontributes a novel function for the replication/infectivityof macrophage-tropic HIV-1.We show that macrophage-tropic HIV-1 which expresses the full-length two-exonform of Tat replicates better in monocyte-derived macro-phages(MDM)than an otherwise isogenic virus whichexpresses only the one-exon form of Tat. Similarly, two-exon Tat expressing HIV-1 also replicates better thanone-exon Tat expressing HIV-1 in two different models ofhuman cells/tissue reconstituted SCID mice.
- 中文關鍵字: --
- 英文關鍵字: HIV. Macrophage tropism. Tat. AIDS pathogenesis. SCID mounse