• 作者： Chen, Chiun-Nan; Wu, Chin-Cheng; Tsai, Chen-Chiet al.
• 中文摘要： 哺乳類動物的心包膜,經交聯劑化學修飾後,常被用來做為心血管補綴片或人工心瓣膜的葉瓣。本研究比較了牛、羊、豬和狗四種不同的哺乳類動物心包膜,經環氧化物交聯處理後的熱穩定性、機械強度、親疏水性、表面張力以及抵抗膠原酵素分解的能力等。藉此選擇一較適當的動物心包膜,以做為心血管補綴片或人工心瓣膜的材料來源。實驗結果顯示,以環氧化物交聯處理後的各式動物心包膜的熱穩定性、機械強度、親疏水性、表面張力以及抵抗膠原酵素分解的能力等皆相似。然而經環氧化物交聯處理後的牛心包膜在酵素分解前後的機械強度,皆較其他動物心包膜來得強。因此,臨床上若需使用機械強度較強的生物補綴片時,可以選擇牛心包膜做為其原料來源。
• 英文摘要： Pericardia from varying mammalian species, chemically modified with a crosslinking reagent, have been used in the cardiovascular surgery as a biological patch or in the construction of heart valve prosthesis. The study was to compare the thermal stability, mechanical strength, wettability, surface tension, and resistance against collagenase degradation of the pericardia from calves, sheep, pigs , and dogs fixed with an epoxy compound. The aim was to expose an appropriate raw material to develop epoxy- fixed pericardial heterografts as alternatives to the glutaraldehyde-fixed prostheses for clinical applications. It was found that the thermal stability, wettability, surface tension, and resistance against collagenase degradation of the pericardia from four species, both before and after chemical modification, were comparable. However, the bovine pericardium appeared to have a better mechanical strength than the other species. Therefore, if mechanical strength is an issue to be taken into account for assessing the performance of pericardial heterografts, the bovine pericardium seems to be the choice of raw material for constructing the prostheses.
• 中文關鍵字： 環氧化物; 哺乳類; 心包膜; 交聯; 膠原; 機械強度
• 英文關鍵字： Epoxy Compound; Mammalian; Pericardia; Hetero Graft; Collagen; Mechanical Strength