第10卷‧第10期,
198210
, pp. 879-889
抗組織胺劑二苯海拉明的試製
- 作者:
楊美惠; 唐永興
- 作者服務機構:
國立臺灣大學化學研究所
- 中文摘要:
二苯海拉明根據文獻資料可經由數種不同途徑合成,但這些文戲都是各國的專利,各合成法中之有效條件實際上仍屬未知,本篇報告中由已知的知識配合國內原始原料之供應情形,以及設備之可能性,詳細檢討了各種可能之製備途徑,已確認以二苯甲烷或二苯甲酮為原料之數種合成合法之可行性。
- 英文摘要:
Synthetic processes leading to the typicalantihistamine agent diphenhydramine, can beclassified into two types: (I) formation of theether linkage as the fihal step, and (II) substit-ution by the amino group as the final step.Most of the literatures concerning the synthesisof diphenhydramine are all abstracts of patentsof merny nations, and the informations of thedetailed reaction conditions are strictly limited.Reexamination and improvement in some exp-erimental equipments and reaction conditionsshown that the methods using diphenylmethaneor benzophenone as starting materials are read-ily available.
- 中文關鍵字:
--
- 英文關鍵字:
--