- 作者: 彭明聰; 程裕婷; 洪淑慧; 楊志良
- 作者服務機構: 國立臺灣大學醫學院生理學科; 國立臺灣大學醫學院公共衛生學系
- 中文摘要: Long-Evans雄雌鼠各八隻,由其年齡3個月到21個月,每3個月檢查食量及飲水行為,檢查項目包括用餐次數,每餐時間,每餐間隔,一餐中攝取頻率,一飲次數,一飲時問,每飲間隔,每飲中之飲水頻率。雌鼠的用餐次數,一飲次數及一餐中攝食頻率比同年齡雄鼠大而雄鼠的每餐間隔,每飲中飲水頻率比同年齡雌鼠大。用餐次數,每餐間隔及一餐中攝食頻率之性別差到21個月時消失。雄鼠之用餐次數,雌鼠之每餐間隔,雄鼠之每飲中飲水頻率的日夜間差21個月時消失,一餐中攝食頻率的日夜間差在雄鼠15個月,在雌鼠18個月時消失。 用餐次數,一餐中攝食頻率,飲水次數及一飲次數在高齡時變化最明顯。前兩項行為之高齡時變化在雄鼠比雌鼠顯著而早出現。飲水行為的各種範型高齡時的變化比食量各種範型的變化少。 以上結果顯示雖然食量及飲水行為各種範型高齡時的變化不是同時出現,其程度也不同,食量的變化比飲水行為的變化大而雄鼠的變化比雌鼠大。用餐次數,一餐中攝食頻率及飲水次數可作食量及飲水行為高齡時變化的指標。
- 英文摘要: Circadian rhythms and patterns of feeding and drinking behavior of 8 male and 8 female Long-Evans rats were followed from 3 months of age (mo) to 21 mo at 3 month intervals. Meal number, draftnumber and feeding events/min/meal of female rats were greater than those of male rats of the same age,while intermeal intervals, interdraft intervals and licking events/min/draft of male rats were greater thanthose of female rats. Sex differences of meal number, intermeal intervals and feeding events/min/meal asa group disappeared by 21 mo. Light/dark differences of meal number of both sexes, intermeal intervalsof females and licking events/min/draft of males as a group also disappeared by 21 mo and difference offeeding events/min/meal disappeared by 15 and 18 mo in males and females, respectively. Occurrence ofage-related change varied from 6 to 21 mo depending upon the parameter of the behavior and period (lightor dark). Meal number and feeding events/min/meal showed the most clear-cut age-related changes and thedecline occurred earlier and was more remarkable in males than in females. The age-related decline of pat-terns and the power spectrum of drinking behavior was less prominent than that of feeding behavior. Theseresults indicate that feeding behavior is more affected by the aging process than is the drinking behaviorof rats, and that male rats show more prominent aging changes than females. Among parameters of feedingand drinking behavior, circadian rhythms of daily feeding events, meal number, feeding events/min/meal,daily licking events and draft number showed clear-cut age-related changes and they seem to be goodmarkers of the aging processes of feeding and drinking behavior.
- 中文關鍵字: age-related change; circadian rhythm; drinking behavior; feeding behavior; sex differences
- 英文關鍵字: --