- 作者: --
- 作者服務機構: Chemistry Department, Faculty of Sciences, Razi University, Kermanshah, Iran
- 中文摘要: Diclofenac sodium (DS) is a drug with analgesic, antipyretic, and anti-inflammatory properties. It is present in numerous pharmaceutical preparations. In injectable forms, it is usually accompanied by benzyl alcohol (BA) as an excipient, which is used as a blocking anesthetic (4%) and an antiseptic (4-10%). In this work a spectrophotometric methodology was applied in order to determine benzyl alcohol and diclofenac in injectable formulations by applying a multivariate calibration method. By a multivariate calibration method such as partial least squares (PLS), it is possible to obtain a model adjusted to the concentration values of the mixtures used in the calibration range. In this study, the concentration model is based on absorption spectra in the 230-320 nm range for 25 different mixtures of benzyl alcohol and diclofenac. Calibration matrix contains 10-95 and 1-50 mg mL-1 for benzyl alcohol and diclofenac, respectively. The root mean square errors of prediction (RMSEP) for benzyl alcohol and diclofenac were 3.0776 and 1.7557, respectively. The proposed method was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneous determination of benzyl alcohol and diclofenac in two different pharmaceutical formulations.
- 英文摘要: --
- 中文關鍵字: Benzyl alcohol; Diclofenac; Spectrophotometry; Partial least squares.
- 英文關鍵字: --