- 作者: Pei-Min Chen; Men-Luh Yen; Ko-Jiunn Liu; Huey-Kang Sytwu; B. Linju Yen
- 作者服務機構: Regenerative Medicine Research Group, Institute of Cellular and System Medicine, National Health Research Institutes (NHRI), Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
In recent years, a large number of studies have contributed to our understanding of the
immunomodulatory mechanisms used by multipotent mesenchymal stem cells
(MSCs). Initially isolated from the bone marrow (BM), MSCs have been found in
many tissues but the strong immunomodulatory properties are best studied in BM
MSCs. The immunomodulatory effects of BM MSCs are wide, extending to T
lymphocytes and dendritic cells, and are therapeutically useful for treatment of
immune-related diseases including graft-versus-host disease as well as possibly
autoimmune diseases. However, BM MSCs are very rare cells and require an invasive
procedure for procurement. Recently, MSCs have also been found in fetal-stage
embryo-proper and extra-embryonic tissues, and these human fetal MSCs (F-MSCs)
have a higher proliferative profile, and are capable of multilineage differentiation as
well as exert strong immunomodulatory effects. As such, these F-MSCs can be
viewed as alternative sources of MSCs. We review here the current understanding of
the mechanisms behind the immunomodulatory properties of BM MSCs and F-MSCs.
An increase in our understanding of MSC suppressor mechanisms will offer insights
for prevalent clinical use of these versatile adult stem cells in the near future. - 中文關鍵字: --
- 英文關鍵字: mesenchymal stem cells, bone marrow, fetal, multilineage differentiation, immunomodulation, T lymphocytes, natural killer lymphocytes, dendritic cells, major histocompatibility complex (MHC) molecules