• 作者： Nafisur Rahman, Yasmin Ahmad, Syed Najmul Hejaz Azmi and Saba A. J. Sulaiman
• 作者服務機構： Department of Chemistry, Aligarh Muslim University, Aligarh-202002, Uttar Pradesh, India
• 中文摘要： The main aim of this work is to develop and validate a spectrophotometric method for the determination of nicorandil in commercial tablets. The method is based on the reduction of the nitroxy ethyl group of nicorandil into carbonyl compound and nitrite ion by NH4Cl and Zn dust. The nitrite ion thus formed reacts with potassium iodide and starch in dilute HCl medium to form a blue product, which absorbs maximally at 550 nm. Beer’s law is obeyed in the concentration range 0.4-4.0μg mL-1 with molar absorptivity of 7.92  104 L mol-1 cm-1. The detection limit is 0.017μg mL-1. The reaction conditions are optimized and validated as per the International Conference on Harmonisation guidelines (USA). The proposed method has been applied successfully for the determination of nicorandil in commercial tablets. The results of analyses are compared statistically with those of the author’s spectrophotometric method, which confirmed that there is no significant difference between the methods compared.
• 英文摘要： --
• 中文關鍵字： Nicorandil; Commercial tablets; Spectrophotometry; Validation.
• 英文關鍵字： --