- 作者: Shih-Chang Lin; Chia-Chen Kuo; Chia-Hsi Chan
- 作者服務機構: 1 Division of Allergy and Immunology, Department of Internal Medicine, Cathay General Hospital, 280 Jen-Ai Rd Section 4, Taipei, Taiwan; ; 2 The Laboratory of Allergy and Immunology, Cathay Medical Research Institute, Hsichih, Taipei Shien, Taiwan; ; 3 Department of Medicine, School of Medicine, Fu Jen Catholic University, Hsinchuang, Taipei Shien, Taiwan
- 中文摘要: --
- 英文摘要: B and T lymphocyte attenuator (BTLA) is an immuno-inhibitory receptor with the ability to deliver inhibitory signal for suppressing lymphocyte activation. To test the potential association of the human BTLA gene with the development of rheumatoid arthritis (RA), a genetic case-control association study was conducted, by using a single nucleotide polymorphism (SNP), C+800T SNP, in the exon 5 of the human BTLA gene for genotyping 93 RA patients and 294 normal control individuals. The results showed that there is statistically significant difference in the genotype distributions between RA and control groups (p = 0.022). When compared with the heterozygous genotype (C/T genotype), the homozygous genotype (C/C or T/T genotype) appears to confer the increased risk of the RA susceptibility with the odds ratio of 1.88 (p = 0.015). These data indicate the significant association between the C + 800T SNP in the BTLA gene with the RA susceptibility.
- 中文關鍵字: --
- 英文關鍵字: B and T lymphocyte attenuator (BTLA), rheumatoid arthritis (RA), single nucleotide polymorphism (SNP)