- 作者: Masayoshi Yamaguchi
- 作者服務機構: Department of Foods and Nutrition, The University of Georgia, Rhodes Center, GA, USA
- 中文摘要: --
- 英文摘要:
Bone homeostasis is maintained through a balance between osteoblastic bone formation and
osteoclastic bone resorption. Aging induces bone loss due to decreased osteoblastic bone
formation and increased osteoclastic bone resorption. Osteoporosis with its accompanying
decrease in bone mass is widely recognized as a major public health problem. Nutritional
factors may play a role in the prevention of bone loss with aging. Among various carotenoids
(carotene and xanthophylls including β-cryptoxanthin, lutein, lycopene, β-carotene,
astaxanthin, and rutin), β-cryptoxanthin, which is abundant in Satsuma mandarin orange
(Citrus unshiu MARC.), has been found to have a stimulatory effect on bone calcification in
vitro.β-Cryptoxanthin has stimulatory effects on osteoblastic bone formation and inhibitory
effects on osteoclastic bone resorption in vitro, thereby increasing bone mass. β-
Cryptoxanthin has an effect on the gene expression of various proteins that are related
osteoblastic bone formation and osteoclastic bone resororption in vitro. The intake of β-
cryptoxanthin may have a preventive effect on bone loss in animal models for osteoporosis
and in healthy human or postmenopausal women. Epidemiological studies suggest a potential
role of β-cryptoxanthin as a sustainable nutritional approach to improving bone health of
human subjects. β-Cryptoxanthin may be an osteogenic factor in preventing osteoporosis in
human subjects. - 中文關鍵字: --
- 英文關鍵字: Carotenoid, β-cryptoxanthin, Osteoblastic bone formation, Osteoclastic bone resorption, Osteoporosis