• 作者： Chih-Chia Chiang, Ling-Yih Hsu*, Tsu-Chung Chang* and Hou-Jen Tsai
• 作者服務機構： Department of Biological Science and Technology, China Institute of Technology, Nangang, Taipei, Taiwan, R.O.C.
• 中文摘要： In the photoaging process of skin, the ultraviolet (UV)-induced reactive oxygen species (ROS) is the key regulator of matrix metalloproteinase (MMPs) expression. In this study, a series of Caffeic acid phenethyl ester (CAPE) analogues were synthesized by conjugating the group VI elements (selenium, sulfur, oxygen)-containing aliphatic alcohols to polyphenolic acids. Their biological activities were evaluated by in vitro testing of their radical scavenging activity the of ABTS [2,2'-azinobis-(3-ethyl-benzo-thiazoline-6-sulfonic acid)] radical and inhibitory effect against the matrix metalloproteinase-1 (MMP-1) activity of collagen degradation and cytotoxicity of a human dermal fibroblast skin cell. Our results suggest these compounds displayed moderate anti-free radical, potent MMP-1 inhibitory, and low cytotoxic activities.
• 英文摘要： --
• 中文關鍵字： CAPE; ABTS radical; MMP-1 inhibitor.
• 英文關鍵字： --