- 作者: Chieh-Sen Chuang, Hong-Lin Su, Fu-Chou Cheng, Shan-Hui Hsu, Chi-Fen Chuang, Chin-San Liu
- 作者服務機構: Department of Neurology, Changhua Christian Hospital, Changhua City 500, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Although gait change is considered a useful indicator of severity in animal models of
Parkinson’s disease, systematic and extensive gait analysis in animal models of
neurological deficits is not well established. The CatWalk-assisted automated gait
analysis system provides a comprehensive way to assess a number of dynamic and
static gait parameters simultaneously. In this study, we used the Catwalk system to
investigate changes in gait parameters in adult rats with unilateral 6-OHDA-induced
lesions and the rescue effect of dopaminergic neuron transplantation on gait function.
Four weeks after 6-OHDA injection, the intensity and maximal area of contact were
significantly decreased in the affected paws and the swing speed significantly
decreased in all four paws. The relative distance between the hind paws also increased,
suggesting that animals with unilateral 6-OHDA-induced lesions required all four
paws to compensate for loss of balance function. At 8 weeks post-transplantation,
engrafted dopaminergic neurons expressed tyrosine hydroxylase. In addition, the
intensity, contact area, and swing speed of the four limbs increased and the distance
between the hind paws decreased. Partial recovery of methamphetamine-induced
rotational response was also noted. - 中文關鍵字: --
- 英文關鍵字: --