- 作者: Hsin-Su Yu; Chung-Hisng Chang; Gwo-Shing Chen; Sen-An Yang ; Chia-Li Yu
- 作者服務機構: a Department of Dermatology, School of; Medicine and Graduate Institute of; Medicine, Kaohsiung Medical College, and; b Section of Allergy, Immunology and; Rheumatology, Department of Medicine, Veterans General Hospital-Taipei, Taiwan, Republic of China
- 中文摘要: --
- 英文摘要: The cutaneous microcirculation can be divided into thermoregulatory shunt vessels and nutritive skin capillaries. Flux in nonnutritional shunt vessels dominates the signal recorded by the laser Doppler flowmeter. Computerized videophotometric capillaroscopy is a sensitive method for assessing cutaneous nutritive microcirculation. Using patients with blackfoot disease and arterio- sclerosis as disease models, we evaluated the sensitivity and clinical usefulness of these relatively new techniques for peripheral vascular disorders. In black- foot disease, blood flux measured by the laser Doppler flowmeter in the affected toe was lower than that in the nonaffected toe. In symptom-free fin- gers, blood flow was not significantly different between blackfoot disease and arteriosclerosis. However, blood flow in both diseases was lower than that of the control group. Patients who had the same status of thermoregulatory flow and eyeground arteriosclerotic classification underwent a 1-min arterial occlu- sion of the digits. The postocclusive reactive hyperemia response (PRH) of nailfold capillary loops was evaluated. All parameters for PRH for the cuta- neous nutrient microcirculation including resting capillary blood cell velocity (rCBV), peak capillary blood cell velocity (pCBV) and time to pCBV were more significantly disturbed in the blackfoot disease group than in the arter- iosclerotic group. On the basis of the results of this study, dynamic capillaros- copy provides a new approach for the early detection of circulatory distur- bances resulting from different mechanisms.
- 中文關鍵字: --
- 英文關鍵字: Capillaroscopy; Microcirculation; Blackfoot disease; Arteriosclerosis