- 作者: Rashed, N. ; Mousaad, A. ; Saleh, A.
- 作者服務機構: Chemistry Dept., Alexandria Univ., Alexandria, Egypt
- 中文摘要: Cyclodehydrogenation of the benzalhydrazino derivatives 5 and 6 gave 6-cyano-7-(4-methoxyphenyl)-2- phenyl-5-oxo-1,2,4-triazolo [ 1,5-a ] pyrimidine 8 and 6- cyano-7-(4-methoxyphenyl)-4-methyl-2-phenyl-5-oxo-1,2,4- triazolo [ 1,5-a ] pyrimidine 9 respectively. Methylation, acetylation and benzylation of 8 gave the corresponding N- methyl, acetyl and benzyl derivatives 10-12. Methylation of 5 with dimethylsulfate gave 2-benzalhydrazino-5-cyano-3- methyl-6-(4-methoxyphenyl)-3,4-dihydropyrimidin -4-one 6, of which the reaction with acetic anhydride in pyridine afforded the N-acetylbenzalhydrazino derivative 15. The latter was also prepared from acetylation of 5 followed by methylation with iodomethane. Acetylation of 5 with boiling acetic anhydride afforded the diacetyl derivative 16, whereas its benzylation gave the mono-N-benzyl derivative 14.
- 英文摘要: --
- 中文關鍵字: Pyrimidin-4-One; Hydrazine; Rearrangement; Pyrimidinone Ring Derivative; Synthesis
- 英文關鍵字: 嘧啶-4-酮;□;重排;嘧啶酮環衍生物;合成