- 作者: El-Badawi M. ; Ibrahim, E.S.I. ; Farag, H. et al.
- 作者服務機構: Dept. of Chemistry, Tanta Univ., Tanta, Egypt
- 中文摘要: 5-Arylidenes 1a and 1b, on reaction with ethyl cyanoacetate and diethyl malonate in the presence of ammonium acetate under Michael condensation, yield corresponding pyridine derivatives. Cyclopentapyrimidine derivative can also be obtained by the reaction of 1a with malononitrile in the presence of piperidine. The reaction of 5-arylidene 1b with monochloroacetic acid in an alkaline medium gives the thiazol derivative. Also, spiro-.lbrak.3',5'.rbrak.cyclohexenyl pyrimidine derivative could be obtained from the reaction of 1d with maleic anhydride. On the other hand, 5-arylidene 1e reacts with maleic anhydride to give 2-thiobarbituric acid derivative. The condensation reaction of 2-thiovioluric acid with some hydrazines affords the triazole derivatives. Finally, barbituric acid condenses with isatin to give 5-arylidene 1f, which can be cyclized with phosphorous pentoxide to afford 10.
- 英文摘要: --
- 中文關鍵字: Pyrimidine 2-Oxo-4,6-Dione; Derivative; Pyrimidine; Synthesis; Pyrimidine 2-Thio-4,6-Dione
- 英文關鍵字: 嘧啶;合成;衍生物