- 作者: Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Zuzanna Drulis-Kawa, Kathryn Cater, Petar Knežević, Cyprian Winogradow, Karolina Amaro, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Justyna Rękas & Andrzej Górski
- 作者服務機構: 1.Bacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114, Wrocław, Poland 2.Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, 21000, Novi Sad, Republic of Serbia 3.Department of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, 02-006, Warsaw, Poland 4.Department of Pathogen Biology and Immunology, University of Wrocław, 51-148, Wrocław, Poland 5.Faculty of Life Sciences, University College London, London, WC1E 6BT, UK 6.Infant Jesus Hospital, Medical University of Warsaw, 02-005, Warsaw, Poland 7.Phage Therapy Unit, Medical Center of the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114, Wrocław, Poland 8.Polpharma Biologics S. A., 80-172, Gdańsk, Poland 9.Rush University Medical Center, 1620 W. Harrison St., Chicago, IL, 60612, USA
- 中文摘要:
- 英文摘要:
Bacteriophages (phages) may be used as an alternative to antibiotic therapy for combating infections caused by multidrug-resistant bacteria. In the last decades, there have been studies concerning the use of phages and antibiotics separately or in combination both in animal models as well as in humans. The phenomenon of phage–antibiotic synergy, in which antibiotics may induce the production of phages by bacterial hosts has been observed. The potential mechanisms of phage and antibiotic synergy was presented in this paper. Studies of a biofilm model showed that a combination of phages with antibiotics may increase removal of bacteria and sequential treatment, consisting of phage administration followed by an antibiotic, was most effective in eliminating biofilms. In vivo studies predominantly show the phenomenon of phage and antibiotic synergy. A few studies also describe antagonism or indifference between phages and antibiotics. Recent papers regarding the application of phages and antibiotics in patients with severe bacterial infections show the effectiveness of simultaneous treatment with both antimicrobials on the clinical outcome. - 中文關鍵字:
- 英文關鍵字: Bacteriophage, Antibiotic, Phage–antibiotic synergy, Animal model, Human phage therapy