- 作者: Chia-Yi Yuan, Yih-Jing Lee and Guoo-Shyng Wang Hsu
- 作者服務機構: Graduate Institute of Nutrition and Food Sciences, Fu-Jen Catholic University, Hsinchuang, Taiwan, R.O.C.
- 中文摘要: --
- 英文摘要:
Background: Higher aluminum (Al) content in infant formula and its effects on neonatal brain
development are a cause for concern. This study aimed to evaluate the distribution and
concentration of Al in neonatal rat brain following Al treatment, and oxidative stress in brain
tissues induced by Al overload.
Methods: Postnatal day 3 (PND 3) rat pups (n =46) received intraperitoneal injection of aluminum
chloride (AlCl3), at dosages of 0, 7, and 35 mg/kg body wt (control, low Al (LA), and high Al
(HA), respectively), over 14 d.
Results
Aluminum concentrations were significantly higher in the hippocampus (751.0 ± 225.8 ng/g
v.s. 294.9 ± 180.8 ng/g; p < 0.05), diencephalon (79.6 ± 20.7 ng/g v.s. 20.4 ± 9.6 ng/g;
p < 0.05), and cerebellum (144.8 ± 36.2 ng/g v.s. 83.1 ± 15.2 ng/g; p < 0.05) in the HA group
compared to the controls. The hippocampus, diencephalon, cerebellum, and brain stem of HA
animals displayed significantly higher levels of lipid peroxidative products (TBARS) than the
same regions in the controls. However, the average superoxide dismutase (SOD) activities in
the cerebral cortex, hippocampus, cerebellum, and brain stem were lower in the HA group
than in the controls. The HA animals demonstrated increased catalase activity in the
diencephalon, and increased glutathione peroxidase (GPx) activity in the cerebral cortex,
hippocampus, cerebellum, and brain stem, compared to controls.
Conclusion: Aluminum overload increases oxidative stress (H2O2) in the hippocampus, diencephalon,
cerebellum, and brain stem in neonatal rats. - 中文關鍵字: --
- 英文關鍵字: Aluminum, Neonatal rats, Functional brain tissues, Intraperitoneal injection