- 作者: --
- 作者服務機構: Department of Chemistry, Aligarh Muslim University, Aligarh-202002 (UP), India
- 中文摘要: Hydroxyzine hydrochloride forms two 1:1 inclusion complexes with b-cyclodextrin in aqueous solution as confirmed by the 1H NMR titration and ROESY studies. One complex is formed by the deep penetration of the chlorophenyl ring from the wider rim side, while the mode of entry of the phenyl ring into the b-CD cavity is not clear. The stoichiometry and overall association constant of the complexes have been determined by the treatment of 1H NMR shift data. Some chiral discrimination by the host between the two enantiomers of hydroxyzine hydrochloride is also indicated.
- 英文摘要: --
- 中文關鍵字: Hydroxyzine hydrochloride; b-Cyclodextrin; 1H NMR; ROESY; Inclusion complexes.
- 英文關鍵字: --