- 作者: Fawzy A. Attaby*, Ahmed H. H. Elghandour, Hussein M. Mustafa and Yasser M. Ibrahem
- 作者服務機構: Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
- 中文摘要: Cyanothioacetamide (1) reacted with but-2-enal (2) to give the corresponding 4-methyl-2-sulfanylpyridine-3-carbonitrile (7) which was used as a good starting material for the synthesis of 1-(3-amino-4-methylthieno[2,3-b]pyridin-2-yl)ethan-1-one (10), 3-amino-4-methylthieno[2,3-b]pyridine-2-carboxamide (15), 3-amino-4-methylthieno[2,3-b]pyridine-2-carboxylate (18) and 3-amino-4-methylthieno[2,3-b]pyridin-2-ylarylketone 25a-c through its reactions with each of (1-chloroacetone (8), 3-chloropentane-2,4-dione (11) or ethyl 2-chloro-3-oxo-butanoate (19)), 2-chloroacetamide (13), ethyl 2-chloroacetate (16) and 2-bromo-1-arylethan-1-one 23a-c, respectively. Considering the data of elemental analyses, IR, 1H NMR, mass spectra and theoretical calculations, structures of the newly synthesized heterocyclic compounds were elucidated.
- 英文摘要: --
- 中文關鍵字: Thieno[2; 3-b]pyridin-2-yl)ethan-1-one; Thieno[2; 3-b]pyridine-2-carboxylate; Thieno[2; 3-b]pyridin-2-ylarylketone; 2-Methylthiopyridine-3-carbonitrile and pyrazolo[3; 4-b]pyridine-3-ylamine.
- 英文關鍵字: Thieno[2, 3-b]pyridin-2-yl)ethan-1-one; Thieno[2, 3-b]pyridine-2-carboxylate; Thieno[2, 3-b]pyridin-2-ylarylketone; 2-Methylthiopyridine-3-carbonitrile and pyrazolo[3, 4-b]pyridine-3-ylamine.