- 作者: Ruey-Hwa Chen; Won-Jing Wang; Jean-Cheng Kuo
- 作者服務機構: Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
- 中文摘要: --
- 英文摘要: Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
- 中文關鍵字: --
- 英文關鍵字: anoikis, cell death, cytoskeleton, DAP-kinase, tumor suppressor