• 作者： 施維貞; 李魯元; 紐翰柯柏
• 作者服務機構： 美國肯他基大學醫學中心; 核子醫學科; 生理及生物物理學系
• 中文摘要： 六隻大白鼠以靜脈注射新腎上腺素（Norepinephrine）引致肺水腫以及出血，可利用放射性銦造影顯示法顯現出來。新腎上腺素注射之前及之後施以放射性銦胸前造影並將其動態（每半分鐘一造影）的資料紀錄在電腦；此電腦連接到造影機，電腦滋生的肺一心放射線量之比，由0.4－0.5（於未靜脈注射新腎上腺素）達到1.0－1.4（於實驗結束時）。當放射性銦由靜脈注射後立即與血漿蛋結合成一良好的血管內造影劑，足以偵測肺泡血管膜的完整性。早期的肺水腫臨床上不易測定，藉用此放射性銦造影法以偵測肺水腫，臨床上可能有其價值。
• 英文摘要： Pulmonary edema and/or hemorrhage (PEH) induced by IV injection of norepinephrine was demonstratedin six rats by In-111 chloride lung/heart imaging. The anesthetized rats were positioned under a gamma camerausing a pinhole collimator. After In-111 chloride IV injection, analog thorax images were obtained and dynamicdata were recorded at 30 seconds/frame for 20 min before and after induced PEH. The gamma camera wasinterfaced to a computer which generated the curve of the lung/heart radioactivity ratio which rose from 0.4-0.5at baseline to 1.0-14 at the end of the study. The image after IV norepinephrine injection showed a reversalof the lung/heart radioactivity concentration. In-111 chloride instantly binds to plasma transferrin yieldingan excellent intravascular imaging agent. Leakage of this tracer into alevoli indicates loss of aveolar membranewall competence. Pulmonary edema, as in acute respiratory distress syndrome, is difficult to diagnose radio-graphically and this In-111 chloride lung/heart imaging technique may be potentially useful.
• 中文關鍵字： Radionuclide defection of pulmonary edema
• 英文關鍵字： --