- 作者: 陳阿煌,顏秀航,陳文章,洪志熙,袁守賓,陳婉怡
- 作者服務機構: Department of Chemical and Materials Engineering, Southern Taiwan University of Technology, Yungkang City, Tainan Hsien, Taiwan 710, R.O.C.
- 中文摘要: Nucleophilic substitution reactions of diethyl 2-chloroazulene-1,3-dicarboxylate with four alkyl lithiums (methyl lithium, ethyl lithium, n-propyl lithium and n-butyl lithium) afforded the major product of ethyl 2-chloro-4-alkylazulene-1-carboxylate and some minor products of 2-chloro-4-alkylazulene, 2,4-dialkylazulene-1-carboxylic acid, ethyl 3,4-dialkylazulene-1-carboxylate, diethyl 6-alkylazulene-1,3-dicarboxylate and diethyl 2-chloro-5-alkylazulene-1,3-dicarboxylate, respectively. The kinds and the yields of their products were significantly dependent on the kinds of alkyl lithiums, molar ratios of alkyl lithium/substrate and oxidation conditions at room temperature or under reflux. The major product of ethyl 2-chloro-4-alkylazulene-1-carboxylate is proposed to be formed via an addition-elimination mechanism.
- 英文摘要: --
- 中文關鍵字: Azulene; Nucleophilic substitution; Addition-elimination mechanism; Alkyl lithium.
- 英文關鍵字: --