- 作者: 簡敦誠、郭佳琦、陳建樹、陳基旺
- 作者服務機構: School of Pharmacy, College of Medicine, National Taiwan University, Taipei 100, Taiwan, R.O.C.
- 中文摘要: Isoguanosine (3) underwent a coupling reaction with diaryl disulfides in the presence of tri-n-butylphosphine when its 6-amino group was protected by N,N-dimethylaminomethylidene. The synthesis of 5'-deoxy-N3,5'-cycloisoguanosine (6) and its 2',3'-O-isopropylidene derivative (11) were accomplished in excellent yields from isoguanosines (3 & 10) in the presence of triphenylphospine and carbon tetrachloride in pyridine. Chlorination at the 5'-position of isoguanosine (3) with thionyl chloride followed by the aqueous base-promoted cyclization afforded the same product 6. The structures were elucidated by spectroscopic analysis including IR, UV, 1-D and 2-D NMR.
- 英文摘要: --
- 中文關鍵字: Isoguanosine; Cycloisoguanosine; Chlorination; 5'-Thionucleoside.
- 英文關鍵字: --