• 作者： 張丙龍; 洪玉海
• 作者服務機構： 國立臺灣大學醫學院解剖學科; 國立陽明醫學院解剖學科
• 中文摘要： 注射六-羥多巴胺後雄性倉鼠頸上神經節內之乙醯膽鹼?之量顯著地減少，但注射酪胺刺激交感神經後乙醯膽鹼?之
  量則顯著地增加。注射六-羥多巴胺後以電子顯微鏡觀察時在神經節細胞內之粗面內質網小池內，核周池內及細胞膜上只
  能看到微弱之乙醯膽鹼?。注射酪胺刺激交感神經後在上述神經節細胞各部內同樣地見到微弱之乙醯膽鹼?之存在，但此
  ?在無髓鞘神經內則顯著地增加。由此發現及參照過去之研究結果也許可作一推論為乙醯膽鹼及乙醯膽鹼?是從神經節細
  胞釋放到節後無髓鞘神經內，然後經由此神經運送到松果腺內。以六-羥多巴胺及酪胺處理後神經節細胞內之高氏器內仍
  然有強烈之乙醯膽鹼?存在，顯示神經節細胞能製造此?以維持其所需要最低限度之量。1
• 英文摘要： The superior cervical ganglia of male hamsters treated with 6-hydroxydopamine (6-OHDA) ortyramine and those of untreated control animals were studied by biochemical and ultrahistochemicalenzyme techniques. The acctylcholinesterase (AChE) was markedly decreased in the superior cervicalganglia treated with 6-OHDA, whereas it was increased markedly in the ganglia from animals which receivedtyramine. Ultrastructurally, the AChE activity in the superior cervical ganglia treated with 6-OHDA wasreduced and only a weak enzyme reaction product remained in the rough surfaced endoplasmic reticulum,in the perinuclear space, and on the plasma membranes of the neurons. After the sympathetic nerves havebeen stimulated by tyramine, the AChE activity located in the rough surfaced endoplasmic reticulum andon the plasma membranes of the neurons was decreased, while it was markedly increased in the unmyeli-nated nerve fibers. Based on these results, together with those of the previous studies, we suggest that theacetylcholine and the AChE were released into the postganglionic unmyelinated adrenergic nerve fibersfrom the neurons, and then they were transmitted into the pineal glands. Following treatment with 6-OHDA or tyramine, strong AChE activity remained in the Golgi complex of the neurons suggesting thatthey will produce AChE and maintain the normal storage within the neurons.
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