- 作者: Junpeng Xu & Shan-hui Hsu
- 作者服務機構: 1.Institute of Cellular and System Medicine, National Health Research Institutes, No. 35 Keyan Road, Miaoli, 350401, Taiwan, Republic of China 2.Institute of Polymer Science and Engineering, National Taiwan University, No. 1, Sec. 4 Roosevelt Road, Taipei, 106319, Taiwan, Republic of China
- 中文摘要:
- 英文摘要:
Tissue engineering biomaterials are aimed to mimic natural tissue and promote new tissue formation for the treat‑
ment of impaired or diseased tissues. Highly porous biomaterial scafolds are often used to carry cells or drugs to
regenerate tissue-like structures. Meanwhile, self-healing hydrogel as a category of smart soft hydrogel with the ability
to automatically repair its own structure after damage has been developed for various applications through designs
of dynamic crosslinking networks. Due to fexibility, biocompatibility, and ease of functionalization, self-healing hydro‑
gel has great potential in regenerative medicine, especially in restoring the structure and function of impaired neural
tissue. Recent researchers have developed self-healing hydrogel as drug/cell carriers or tissue support matrices for
targeted injection via minimally invasive surgery, which has become a promising strategy in treating brain diseases.
In this review, the development history of self-healing hydrogel for biomedical applications and the design strategies
according to diferent crosslinking (gel formation) mechanisms are summarized. The current therapeutic progress of
self-healing hydrogels for brain diseases is described as well, with an emphasis on the potential therapeutic applica‑
tions validated by in vivo experiments. The most recent aspect as well as the design rationale of self-healing hydrogel
for diferent brain diseases is also addressed. - 中文關鍵字:
- 英文關鍵字: Self-healing hydrogel, Injectable implant, Neural tissue engineering, Translation medicine, Stroke, Neurodegenerative disease, Traumatic brain injury