- 作者： 張傳炯; 蘇銘嘉; 謝璧華; 林秀麗; 洪士榮
- 作者服務機構： 臺灣大學醫學院藥理學研究所
- 中文摘要：
箭毒素（d-Tubocurarine）所引起之神經一肌傳遞遮斷可分別用抗膽胺脂?藥 Neostigmine 或能增加神經傳遞物釋放
之 3, 4-Diaminopyridine 來對抗而恢復神經一肌間傳遞。用離體小鼠膈神經一膈肌標本以 Neostigmine 或 Diaminopy-
ridine 前處理後箭毒之有效麻痺濃度提高為對照之1.87及2.24倍（以0.1 Hz刺激時）或1.85及1.64倍（以50 Hz攣縮刺激
時）。Neostigmine 及 Diaminopyridine 共用時卻提高箭毒素有效濃度達對照之14.7倍（0.1 Hz）及5.33倍，顯示兩者間
有相互加強作用。但若以對抗箭毒素之致死量比較，在 Neostigmine 與 Diaminopyridine 分別前處理時致死量為
對照之1.21及1.33倍，合用時僅為1.84倍，顯然兩者單獨或合用效果均不理想。偏 - 英文摘要： The antagonisms to the d-tubocurarine-induced neuromuscular blockade by neostigmine and 3,4-diaminopyridine (DAP) were studied quantitatively in the isolated phrenic nerve-diaphragm preparation ofmice in vitro and in lethality of mice in vivo by assaying concentrations of d-tubocurarine needed to pro-duce 70% block of indirect muscle contraction and , respectively. The“antagonist efficacies”, defin-ed as the ratio of d-tubocurarine concentration (dose) after pretreatment with antagonistic agents overthat of control, were 1.87, 2.24 and 14.7, respectively, for neostigmine, DAP and both agents combinedwhen the stimulus pulses were at 0.1 Hz. Under 50 Hz train stimulation, the antagonist efficacies werelower, being 1.85, 1.64 and 5.33, respectively. For the lethality to d-tubocurarine, the values were stilllower, being only 1.21, 1.33 and 1.84, respectively. The synergism between neostigmine and DAP, asevident from the marked increase of antagonist efficacy in vitro, is more than expected from the possibleinteraction of the major pharmacological actions of these two agents.
- 中文關鍵字： neostigmine; aminopyridines; 3,4-diaminopyridine; d-tubocurarine; neuromuscular
- 英文關鍵字： --
