• 作者： 林家立 ; 陳秀娟 ; 孫慧玲
• 作者服務機構： 中興大學化學系
• 中文摘要： Multiply enantioselective enzyme-catalyzed transacylation reactions are described. Two instances of triply enantioselective enzyme-catalyzed transacylations are: (1) the reaction of rac-1-indanol with rac-1,1'-bi-2- naphthyl-2,2'-dibutyrate to afford (S)-1-indanol, (R)-1- indanylacetate, (S)-1,1'-bi-2-naphthyl-2,2'-diol, and (R)- 1,1'-bi-2-naphthyl-2,2'-dibutyrate, and (2) the reaction of rac-1-indanol with rac-2,2'-bis(butyroxymethyl)biphenyl to afford (S)-1-indanol, (R)-1-indanylbutyrate, (S)- 2,2'- biphenyldimethanol, and (R)-2,2'-bis(butyroxy-methyl) biphenyl. Doubly enantioselective enzyme-catalyzed transacylations are described according to two instances:(1) the reaction of rac-1-indanol with rac-1,1'-bi-2- naphthyl-2-ol-2'-butyrate afforded (S)-1-indanol, (R)-1- indanylacetate, (S)-1,1'-bi-2-naphthyl-2,2'-diol, and (R)- 1,1'-bi-2-naphthyl-2-ol-2'-butyrate, and (2) the reaction of rac-1-indanol with 1,3,5-O-methylidne-2,4,6-tri-O- butyrate-myo-inositol to afford (S)-1-indanol, ( R)-1- indanylbutyrate, and 1,3,5-O-methylidne-2,6-di-O-butyrate- myo-inositol. Multiply enantioselective enzyme-catalyzed reactions have a merit of the enhancement of enantiomeric excess over singly enantioselective ones.
• 英文摘要： --
• 中文關鍵字： Optical Isomerism; Selection; Acyltransferase; Enzyme Reaction
• 英文關鍵字： 旋光異構；選擇；醯基轉移；酵素反應